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Enalapril maleate salt is used as a long-acting ACE inhibitor and antihypertensive, used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include: Enalapril, Enalaprilat dihydrate, Enalaprilat, and Enalapril-d5 Maleate Salt, among others.
Sunny Piyush Bhardwaj.; Saranjit Singh. Study of forced degradation behavior of enalapril maleate by LC and LC-MS and development of a validated stability-indicating assay method. Journal of Pharmaceutical and Biomedical Analysis. 2008, 46, (1), 113-120.
Matthew J. Wyvratt.; Edward W. Tristram.; Theodore J. Ikeler.; Nancy S. Lohr.; Henry Joshua.; James P. Springer.; Byron H. Arison.; Arthur A. Patchett. Reductive amination of ethyl 2-oxo-4-phenylbutanoate with L-alanyl-L-proline. Synthesis of enalapril maleate. J. Org. Chem. 1984, 49, (15), 2816-2819.