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19545-26-7 - Wortmannin, Penicillium funiculosum, 99+% - KY 12420 - J63983 - Alfa Aesar

J63983 Wortmannin, Penicillium funiculosum, 99+%

CAS-Nummer
19545-26-7
Synonyme
KY 12420

Größe Preis ($) Menge Verfügbarkeit
10mg 113,30
25mg 214,20
50mg 402,30
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Wortmannin, Penicillium funiculosum, 99+%

MDL
MFCD00133927

Chemische Eigenschaften

Formel
C23H24O8
Molmasse
428.44
Form
Powder
Sensitivität
Light Sensitive
Löslichkeit
Soluble in DMSO, ethanol, methanol, and DMF.

Anwendungen

Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Bemerkungen

Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Mantle, P.G. Secondary Metabolites of Penicillium and Acremonium. Penicillium and Acremonium. 1987, 1, 161-243.

Walter Haefliger.; Daniel Hauser. Isolierung und Strukturaufklärung von 11-Desacetoxy-wortmannin. Helvetica Chimica Acta. 1973, 56, (8), 2901-2904.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H310-H330

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.

Sicherheitshinweise: P260-P284-P301+P310-P304+P340-P320-P330-P361-P302+P350-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,10053
Beilstein
67676
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
CB9641000

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