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94497-51-5 - Tamibarotene - AM 80 - J64028 - Alfa Aesar

J64028 Tamibarotene

CAS-Nummer
94497-51-5
Synonyme
AM 80

Größe Preis ($) Menge Verfügbarkeit
10mg 122,00
50mg 612,00
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Tamibarotene

MDL
MFCD00866188

Chemische Eigenschaften

Formel
C22H25NO3
Molmasse
351.44
Form
Solid
Löslichkeit
Soluble to 50 mM in DMSO

Anwendungen

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literaturverweise

B.A.Bernard; J.M.Bernardon; C.Delescluse; B.Martin; M.C.Lenoir; J.Maignan; B.Charpentier; W.R.Pilgrim; U.Reichert; B.Shroot. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992, 186,(2), 977-983.

 

Shiro Jimi; Kota Mashima; Taichi Matsumoto; Shuji Hara; Junji Suzumiya; Kazuo Tamura. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. International Journal of Oncology. 2007, 31,(2), 397-404.

Weitere Referenzen

Merck
14,9047
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
DH6940000

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