Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

335165-69-0 - Bax Channel Blocker - 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol bis(trifluoracetate) salt - J64257 - Alfa Aesar

J64257 Bax Channel Blocker

CAS-Nummer
335165-69-0
Synonyme
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol bis(trifluoracetate) salt

Größe Preis ($) Menge Verfügbarkeit
10mg 154,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Bax Channel Blocker

MDL
MFCD09037523

Chemische Eigenschaften

Formel
C19H21Br2N3O.2CF3CO2H
Molmasse
695.24
Form
Powder
Sensitivität
Light Sensitive & Hygroscopic
Löslichkeit
Soluble in water at 5mM or in DMSO at 100mM

Anwendungen

Bax Channel Blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 M). It is suggested to inhibit Bax (Bcl-2-associated X protein) channel formation and activity.

Bemerkungen

Light sensitive and hygroscopic. Incompatible with oxidizing agents and heat.

Literaturverweise

Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax Channel Modulation. J. Med. Chem. 2003, 46,(21), 4365-4368.

 

Elisabete Ferreiro; Catarina R.Oliveira; Claudia M.F.Pereira. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiology of Disease. 2008, 30,(3), 331-342.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H341

Suspected of causing genetic defects.

Sicherheitshinweise: P201-P280-P202-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
3822.00
TSCA
No

Empfohlen

  • J67510

    TRIS-HCl, 0.5M buffer soln., pH 8.0, low endotoxin
  • H53119

    2-Methyl-5-(-1-piperidinylsulfonyl)benzeneboronic acid, 98%
  • J67399

    Fibroblast Growth Factor 8, mouse
  • A18906

    Boc-ON, 98+%
  • 13344

    Silver single crystal, 15mm (0.59in) dia, 100mm (3.9in) long, (111) orientation, ±2°

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf