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211990-57-7 - N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin - Ac-IETD-AFC - J64258 - Alfa Aesar

J64258 N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin

CAS-Nummer
211990-57-7
Synonyme
Ac-IETD-AFC

Größe Preis ($) Menge Verfügbarkeit
5mg 190,55
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N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin

MDL
MFCD02094703

Chemische Eigenschaften

Formel
C31H38F3N5O12
Molmasse
729.65
Form
Lyophilized powder
Löslichkeit
Soluble in DMSO

Anwendungen

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literaturverweise

Markus Selzner; Hannes A.Rudiger; Nazia Selzner; Dennis W.Thomas; David Sindram; Pierre-Alain Clavien. Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion. Journal of Hepatology. 2002, 36,(2), 218-225.

 

Nazia Selzner; Markus Selzner; Wolfram Jochum; Pierre-Alain Clavien. Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism. Journal of Hepatology. 2003, 39,(1), 55-61.

Weitere Referenzen

Harmonized Tariff Code
2932.20
TSCA
No

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