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Bovine Pituitary Extract (BPE) is an extract prepared from bovine pituitary glands. BPE, also known as keratinocyte growth supplement, is used in conjunction with other growth factors, hormones and media to reduce or eliminate serum in the culturing of some epithelial cell types. BPE has been effectively utilized in culturing normal human epidermal keratinocytes (Tsao, M.C., et al, J. Cell Physiol. 110: 219-229, 1982) and other epithelial cells. BPE is a membrane filtered and packaged as a lyophilized solid.Bovine pituitary extract is used as a mitogenic supplement in a serum-free growth medium. It has been reported to provide protection against hydrogen peroxide induced cell death, protein oxidation, membrane fragmentation and deoxyribonucleic acid damage.
Xu, Z. Z.; Li, Z. J.; Du, L. X.; Li, J.; Wang, L. Y. Using bovine pituitary extract to increase proliferation of keratocytes and maintain their phenotype in vitro. Int J Ophthalmol. 2013, 6 (6), 758-765.
Kuo, Y. C.; Wang, C. C. Effect of bovine pituitary extract on the formation of neocartilage in chitosan/gelatin scaffolds. J. Taiwan Inst. Chem. Eng. 2010, 41 (2), 150-156.