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17397-89-6 - Cerulenin, 98% - (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide - J64538 - Alfa Aesar

J64538 Cerulenin, 98%

CAS-Nummer
17397-89-6
Synonyme
(2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide

Größe Preis ($) Menge Verfügbarkeit
5mg 115,00
10mg 229,69
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Cerulenin, 98%

MDL
MFCD00077686
EINECS
241-424-8

Chemische Eigenschaften

Formel
C12H17NO3
Molmasse
223.27
Form
Powder
Löslichkeit
Soluble in acetone at 20mg/ml. Also soluble in ethanol, benzene, chloroform, or ethyl acetate.

Anwendungen

Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.

Bemerkungen

Keep container tightly closed. Store in cool, dry conditions in well sealed containers..

Literaturverweise

Sakari Kauppinen.; Mads Siggaard-Andersen.; Penny von Wettstein-Knowles. β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue. Carlsberg Research Communications. 1988, 53, (6), 357-370.

Giuliano D'agnony.; Ira S. Rosenfeld.; Juichi Awaya.; Satoshi Omura.; Roy Vagelos, P. Inhibition of fatty acid synthesis by the antibiotic cerulenin: Specific inactivation of β-ketoacyl-acyl carrier protein synthesize. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1973, 326, (2), 155-166.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302

Harmful if swallowed.

Sicherheitshinweise: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2004
Beilstein
4140423
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
JR1670000

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