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Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin - Z-DEVD-AFC - Z-Asp-Glu-Val-Asp-AFC - J64569 - Alfa Aesar

J64569 Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin

CAS-Nummer
Synonyme
Z-DEVD-AFC
Z-Asp-Glu-Val-Asp-AFC

Größe Preis ($) Menge Verfügbarkeit
5mg 120,00
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Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin

MDL
MFCD01074977

Chemische Eigenschaften

Formel
C36H38F3N5O14
Molmasse
821.71
Form
Powder
Löslichkeit
Soluble in dimethyl sulfoxide.

Anwendungen

Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10. The reaction can be observed by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.

Bemerkungen

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Jiuru Sun.; Stephen P. Bottomley.; Sharad Kumar.; Phillip I. Bird. Recombinant Caspase-3 Expressed inPichia pastorisIs Fully Activated and Kinetically Indistinguishable from the Native Enzyme. Biochemical and Biophysical Research Communications. 1997, 238 (3), 920-924.

Kieran F. Harvey.; Natasha L. Harvey.; Julie M. Michael.; Gayathri Parasivam.; Nigel Waterhouse.; Emad S. Alnemri?.; Dianne Watters.; Sharad Kumar. Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis. The Journal of Biological Chemistry. 1998, 273 13524-13530.

Weitere Referenzen

Harmonized Tariff Code
2932.20
TSCA
No

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