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42155-08-8 - 2'-Deoxyuridine-5'-monophosphate disodium salt, 99% - 2'-dUMP - 2'-Deoxyuridine-5'-monophosphoric acid disodium salt - J64627 - Alfa Aesar

J64627 2'-Deoxyuridine-5'-monophosphate disodium salt, 99%

CAS-Nummer
42155-08-8
Synonyme
2'-dUMP
2'-Deoxyuridine-5'-monophosphoric acid disodium salt

Größe Preis ($) Menge Verfügbarkeit
250mg 85,70
1g 172,00
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2'-Deoxyuridine-5'-monophosphate disodium salt, 99%

MDL
MFCD00065282
EINECS
255-687-1

Chemische Eigenschaften

Formel
C9H11N2Na2O8P
Molmasse
352.15
Form
Powder
Löslichkeit
Soluble in water.

Anwendungen

2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

Bemerkungen

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Ruth L. Saxl.; James Reston.; Zhe Nie.; Thomas I. Kalman.; Frank Maley. Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2‘-deoxyuridine 5‘-Monophosphate. Biochemistry. 2003, 42 (15), 4544-4551.

Mikhail V. Rekharsky.; Asao Nakamura.; Guy A. Hembury.; Yoshihisa Inoue. Thermodynamic Study of the Discrimination between Uridine and Thymidine Derivatives by Hydrophobic, Stacking, and Intercalating Interactions. Bulletin of the Chemical Society of Japan. 2001, 74 (3), 449-457.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2934.99
TSCA
No

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