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300801-52-9 - Cdc2-Like Kinase Inhibitor, TG003 - Clk Inhibitor - TG003 - J64690 - Alfa Aesar

J64690 Cdc2-Like Kinase Inhibitor, TG003

CAS-Nummer
300801-52-9
Synonyme
Clk Inhibitor
TG003

Größe Preis ($) Menge Verfügbarkeit
5mg 70,74
50mg 471,60
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Cdc2-Like Kinase Inhibitor, TG003

MDL
MFCD00624584

Chemische Eigenschaften

Formel
C13H15NO2S
Molmasse
249.33
Form
Solid
Sensitivität
Light Sensitive
Löslichkeit
Soluble in DMSO

Anwendungen

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Bemerkungen

Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light.

Literaturverweise

Yasushi Ogawa.; Yosuke Nonaka.; Toshiyasu Goto.; Eriko Ohnishi.; Toshiyuki Hiramatsu.; Isao Kii.; Miyo Yoshida.; Teikichi Ikura.; Hiroshi Onogi.; Hiroshi Shibuya.; Takamitsu Hosoya.; Nobutoshi Ito.; Masatoshi Hagiwara. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Communications. 2010, 1 86.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2934.20
TSCA
No

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