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Acetylene-PEG4-maleimide - 3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide - J64859 - Alfa Aesar

J64859 Acetylene-PEG4-maleimide

CAS-Nummer
Synonyme
3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide

Größe Preis ($) Menge Verfügbarkeit
25mg 103,00
100mg 245,00
500mg 823,00
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Acetylene-PEG4-maleimide

MDL
MFCD22380740

Chemische Eigenschaften

Formel
C18H26N2O7
Molmasse
382.41
Form
Viscous liquid or solid
Löslichkeit
Soluble in water.

Anwendungen

Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility

Bemerkungen

Keep container tightly closed. Store away from oxidizing agents.

Literaturverweise

Hao Jiang.; Tianqing Zheng.; Aime Lopez-Aguilar.; Lei Feng.; Felix Kopp.; Florence L. Marlow.; Peng Wu. Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem. 2014, 25, (4), 698-706.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2925.29
TSCA
No

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