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Orexin is a neuropeptide that modulates the energy and metabolism balance. The effects of orexin are mediated by one of the two G protein-coupled receptors, orexin receptor 1 or 2. OXRs are expressed in oxinergic projection areas of the brain and regulate food intake by reducing systemic and brain signals that drive over-eating. Synthetic peptide corresponding to the C-terminus of human orexin receptor 1, conjugated to KLH. The immunizing peptide has 70% homology with the rat and mouse gene.
Kousaku Ohno.; Takeshi Sakurai. Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness. Frontiers in Neuroendocrinology. 2008, 29, (1), 70-87.
Katayama, S.; Hamasu, K.; Shigemi, K.; Cline, M.A.; Furuse, M. Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2010, 157, (2), 132-135.