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102121-60-8 - AM 580 - 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid - J65155 - Alfa Aesar

J65155 AM 580

CAS-Nummer
102121-60-8
Synonyme
4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid

Größe Preis ($) Menge Verfügbarkeit
10mg 141,30
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AM 580

MDL
MFCD00673916

Chemische Eigenschaften

Formel
C22H25NO3
Molmasse
351.44
Form
Crystalline solid
Löslichkeit
Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).

Anwendungen

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.

Bemerkungen

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Literaturverweise

S C Brooks; S Kazmer; A A Levin; A Yen. Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs. Blood . 1996, 87, (1), 227-237.

M Gianni; M Li Calzi; M Terao; G Guiso; S Caccia; T Barbui; A Rambaldi; E Garattini.AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996, 87, (4), 1520-1531.

Weitere Referenzen

Harmonized Tariff Code
2924.29
TSCA
No
RTECS
DH6834890

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