Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.
S C Brooks; S Kazmer; A A Levin; A Yen. Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs. Blood . 1996, 87, (1), 227-237.
M Gianni; M Li Calzi; M Terao; G Guiso; S Caccia; T Barbui; A Rambaldi; E Garattini.AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996, 87, (4), 1520-1531.