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IGF-II (insulin-like Growth Factor-II) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types. The biological activity is measured in a serum-free cell proliferation assay using the human cell line MCF-7.
Ioannis D. Xynos; Alasdair J. Edgar; Lee D.K. Buttery; Larry L. Hench; Julia M. Polak. Ionic Products of Bioactive Glass Dissolution Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II mRNA Expression and Protein Synthesis. Biochemical and Biophysical Research Communications. 2000, 276, (2), 461-465.
Morgan DO; Edman JC; Standring DN; Fried VA; Smith MC; Roth RA; Rutter WJ. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 1987, 329, (6137), 301-307.