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FBPase-1 Inhibitor that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. FBPase-1 Inhibitor has been shown to block glucose production in starved rat hepatoma cells.
Chunqiu Lai; Rebecca J. Gum; Melissa Daly; Elizabeth H. Fry; Charles Hutchins; Celerino Abad-Zapatero; Thomas W. von Geldern. Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorganic & Medicinal Chemistry Letters. 2006, 16, (7), 1807-1810.
Thomas W. von Geldern; Chunqiu Lai; Rebecca J. Gum; Melissa Daly; Chaohong Sun; Elizabeth H. Fry; Celerino Abad-Zapatero. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorganic & Medicinal Chemistry Letters. 2006, 16, (7), 1811-1815.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.