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PYR 41 is an irreversible and cell-permeable UBE1 inhibitor.
A G Eldridge and T O'Brien. Therapeutic strategies within the ubiquitin proteasome system. Cell Death and Differentiation. 2010, 17, 4-13.
Dana Ungermannova; 1Seth J. Parker; Christopher G. Nasveschuk; Douglas A. Chapnick; Andrew J. Phillips; Robert D. Kuchta Xuedong Liu. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen. 2012, 17, (4), 421-434.
Gefahrenhinweise (EU): H302-H317
Harmful if swallowed. May cause an allergic skin reaction.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.