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Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone - Z-IETD-FMK - Caspase-8 inhibitor - J65505 - Alfa Aesar

J65505 Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

CAS-Nummer
Synonyme
Z-IETD-FMK
Caspase-8 inhibitor

Größe Preis ($) Menge Verfügbarkeit
1mg 235,00
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Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

MDL
MFCD01861686

Chemische Eigenschaften

Formel
C30H43FN4O11
Molmasse
654.68
Form
Powder
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in DMSO

Anwendungen

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.

Bemerkungen

Moisture sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, water/ moisture. Store in refrigerator.

Literaturverweise

Quinn L. Deveraux; Natalie Roy; Henning R. Stennicke; Todd Van Arsdale; Qiao Zhou; Srinivasa M. Srinivasula; Emad S. Alnemri; Guy S. Salvesen; John C. Reed. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. The EMBO Journal. 1998, 17, (8), 2139 - 2449.

Li Yu; Ajjai Alva; Helen Su; Parmesh Dutt; Eric Freundt; Sarah Welsh; Eric H. Baehrecke; Michael J. Lenardo. Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8. Science. 2011, 304, (5676), 1500-1502.

Weitere Referenzen

Harmonized Tariff Code
2924.29
TSCA
No

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Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf