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Each lot is evaluated in culture with our LDLs to determine the degree of up regulation of LDL receptors.Lipoprotein Deficient Serum human is used in cell culture medium. It inhibits the transfer of unesterified cholesterol from low density lipoprotein to high density lipoprotein. Further, it is useful as media supplement for lipoprotein uptake and metabolism studies.
Martínez-Bujidos, M.; Rull, A.; González-Cura, B.; Pérez-Cuéllar, M.; Montoliu-Gaya, L.; Villegas, S.; Ordóñez-Llanos, J.; Sánchez-Quesada, J. L. Clusterin/apolipoprotein J binds to aggregated LDL in human plasma and plays a protective role against LDL aggregation. FASEB J. 2015, 29 (5), 1688-1700.
Tavori, H.; Fan, D.; Blakemore, J. L.; Yancey, P. G.; Ding, L.; Linton, M. F.; Fazio, S. Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor Evidence for a Reciprocal Regulation. Circulation 2013, 127 (24), 2403-2413.
Rull, A.; Martínez-Bujidos, M.; Pérez-Cuellar, M.; Pérez, A.; Ordóñez-Llanos, J.; Sanchez-Quesada, J. L. Apolipoprotein J distribution among lipoprotein fractions in normolipemia and hyperlipemia. Atherosclerosis 2014, 235 (2), e204-e205.