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An irreversible and cell permeable inhibitor of human leukocyte elastase. Chloromethyl ketones covalently bond to the OH of an adjacent serine residue, or to the SH of an adjacent cysteine residue, on the target protein.
William C. Groutas. Inhibitors of leukocyte elastase and leukocyte Cathepsin G. Agents for the treatment of emphysema and related ailments. Medicinal Research Reviews. 1987, 7, (2), 227-241.
Wei An-Zhi.; Irmgard Mayr.; Wolfram Bode. The refined 2.3 Å crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. FEBS Letters. 1988, 234, (2), 367-373.