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90105-47-8 - Ala-Ala-Pro-Val chloromethyl ketone, 95% - Ala-Ala-Pro-Val-CMK - J66149 - Alfa Aesar

J66149 Ala-Ala-Pro-Val chloromethyl ketone, 95%

CAS-Nummer
90105-47-8
Synonyme
Ala-Ala-Pro-Val-CMK

Größe Preis ($) Menge Verfügbarkeit
5mg 141,00
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Ala-Ala-Pro-Val chloromethyl ketone, 95%

MDL
MFCD00077092

Chemische Eigenschaften

Formel
C17H29ClN4O4
Molmasse
388.89
Form
Solid
Löslichkeit
Soluble in DMSO or DMF.

Anwendungen

An irreversible and cell permeable inhibitor of human leukocyte elastase. Chloromethyl ketones covalently bond to the OH of an adjacent serine residue, or to the SH of an adjacent cysteine residue, on the target protein.

Bemerkungen

Dissolve in DMSO or DMF at 100mM for a stock solution. Dilute in buffer as needed. A twenty minute incubation is suggested for optimum inhibition.

Literaturverweise

William C. Groutas. Inhibitors of leukocyte elastase and leukocyte Cathepsin G. Agents for the treatment of emphysema and related ailments. Medicinal Research Reviews. 1987, 7, (2), 227-241.

Wei An-Zhi.; Irmgard Mayr.; Wolfram Bode. The refined 2.3 Å crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. FEBS Letters. 1988, 234, (2), 367-373.

Weitere Referenzen

Harmonized Tariff Code
2933.99
TSCA
No

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