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D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.
Lei Lv et. al. Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization. Molecular Cell, 2013,52(3), 340-352.
Pranav Puri; Anisha Goel; Agnieszka Bochynska; Bert Poolman. Regulation of acetate kinase isozymes and its importance for mixed-acid fermentation in Lactococcus lactis. Journal of Bacteriology, 2014,196(7), 1386-1393.