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70476-82-3 - Mitoxantrone dihydrochloride - 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride - J66341 - Alfa Aesar

J66341 Mitoxantrone dihydrochloride

CAS-Nummer
70476-82-3
Synonyme
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Größe Preis ($) Menge Verfügbarkeit
50mg 118,45
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Mitoxantrone dihydrochloride

MDL
MFCD00242943
EINECS
274-619-1

Chemische Eigenschaften

Formel
C22H28N4O6.2HCl
Molmasse
517.40
Form
Crystalline solid
Löslichkeit
Soluble to 5 mM in water and to 75 mM in DMSO

Anwendungen

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

Bemerkungen

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literaturverweise

Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.

Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H310-H302-H340-H360

Fatal in contact with skin. Harmful if swallowed. May cause genetic defects. May damage fertility or the unborn child.

Sicherheitshinweise: P201-P262-P280-P281-P361-P302+P350-P310-P301+P312-P405-P501a

Obtain special instructions before use. Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6217
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2922.50
TSCA
No
RTECS
CB5748500

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