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132-92-3 - Methicillin sodium salt, 90+% - Sodium (2,6-dimethoxyphenyl)penicillin - Sodium methicillin - J66414 - Alfa Aesar

J66414 Methicillin sodium salt, 90+%

CAS-Nummer
132-92-3
Synonyme
Sodium (2,6-dimethoxyphenyl)penicillin
Sodium methicillin

Größe Preis ($) Menge Verfügbarkeit
1g 326,00
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Methicillin sodium salt, 90+%

MDL
MFCD07787409
EINECS
205-083-9

Chemische Eigenschaften

Formel
C17H19N2NaO6S
Molmasse
402.40
Form
Powder
Schmelzpunkt
196-197° dec.
Siedepunkt
640°
Flammpunkt
>110°(230°F)
Sensitivität
Light Sensitive
Löslichkeit
Slightly soluble in acetone. Soluble in ethanol or water

Anwendungen

Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.

Bemerkungen

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literaturverweise

Campanella, L.; Mazzei, F.; Sbrilli, R.; Tomassetti, M. Benzylpenicillin PVC membrane electrode for the determination of antibiotics in formulations. Journal of Pharmaceutical and Biomedical Analysis. 1988, 6, (3), 299-305.

Michael Averill Schwartz.; David E. Tutt. Model catalysts which stimulate penicillinase. V. The cycloheptaamylose-catalyzed hydrolysis of penicillins. J. Am. Chem. Soc. 1971, 93, (3), 767-772.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H334-H317-H335

Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.

Sicherheitshinweise: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,5969
Harmonized Tariff Code
2941.10
TSCA
No
RTECS
XH8950000

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