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Doxycycline hydrochloride, is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Z Qiang.; C Adams. Potentiometric determination of acid dissociation constants (pK a) for human and veterinary antibiotics. Water research. 2004, 38, (12), 2874-2890.
JB Bogardus.; RK Blackwood. Solubility of doxycycline in aqueous solution. Journal of Pharmaceutical Sciences. 1979, 68, (2), 188-194.