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Zeocin, a popular and effective antibiotic for the selection of vectors bearing the Sh ble gene in a variety of cells types (bacteria, eukaryotic microorganisms, plant and animal cells). Resistance to Zeocin is conferred by the Sh ble gene product, which inactivates Zeocin by binding to the antibiotic. Sh ble is a small gene, only 370bp in size, carried in a number of InvivoGens vectors. Zeocin is used as a selective agent in molecular genetics experiments.
TA Pfeifer.; DD Hegedus.; TA Grigliatti.; DA Theilmann. Baculovirus immediate-early promoter-mediated expression of the Zeocin resistance gene for use as a dominant selectable marker in Dipteran and Lepidopteran insect cell lines. Gene. 1997, 188, (2), 183-190.
S Takeno.; E Sakuradani.; A Tomi. Transformation of oil-producing fungus, Mortierella alpina 1S-4, using Zeocin, and application to arachidonic acid production. Journal of Bioscience and Bioengineering. 2005, 100, (6), 617-622.
Gefahrenhinweise (EU): H341
Suspected of causing genetic defects.
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