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88899-55-2 - Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered - J67193 - Alfa Aesar

J67193 Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

CAS-Nummer
88899-55-2
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1ml 156,00
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Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

MDL
MFCD06795130

Chemische Eigenschaften

Form
Liquid
Löslichkeit
Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.

Anwendungen

Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H+ ATPase). The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

Bemerkungen

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literaturverweise

E. Papini.; M. Bugnoli.; M. De Bernard.; N. Figura.; R. Rappuoli.; C. Montecucco. Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.Mol. Microbiol. 1993, 7 (2),.1365-2958 .

Daniel J. Klionsky.; Zvulun Elazar.; Per O. Seglen.; David C. Rubinsztein. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy. 2008, 4 (7),849-850 .

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227

Combustible liquid.

Sicherheitshinweise: P210u-P280a-P370+P378a-P403+P235-P501a

Wear protective gloves and eye/face protection. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
RN9781000

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