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25316-40-9 - Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered - J67364 - Alfa Aesar

J67364 Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered

CAS-Nummer
25316-40-9
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1ml 264,71
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Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered

MDL
MFCD00077757
EINECS
246-818-3

Chemische Eigenschaften

Form
Liquid
Löslichkeit
Fully miscible in water and soluble in 50 mM in DMSO, methanol and isotonic sodium chloride (>10 mg/ml). Insoluble in chloroform, and ether.

Anwendungen

It acts as an antitumor antibiotic agent that inhibits DNA topoisomerase II and acts as a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. It reduces intracellular tau levels. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein. It is an is an inhibitor of AMPK, TERT and POLR. its fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. It is applied as an antineoplastic.

Bemerkungen

Protect from heat. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in freezer at -20°C.

Literaturverweise

Patel, S, et. al. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: Implications for the mechanisms of doxorubicin action and cytotoxicity.Mol Pharmacol.,1997,52(4), 658-666.

Lorenzo, E, et al. Doxorubicin induces apoptosis and CD95 gene expressionin human primary endothelial cells through a p53-dependent mechanism.J Biol Chem.,2002,277(17), 10883-10892.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H350

May cause cancer.

Sicherheitshinweise: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
QI9295900

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