Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

3039-71-2 - U-18666A, 95% - 3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride - J67389 - Alfa Aesar

J67389 U-18666A, 95%

3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride

Größe Preis ($) Menge Verfügbarkeit
5mg 68,80
10mg 120,00
25mg 287,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

U-18666A, 95%


Chemische Eigenschaften

Soluble in water at 10mg/ml


Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.


Protect from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.


Koh, C.H.V, et al. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C and Alzheimer’s disease.Cell Signal.,2006,18(11), 1844-1853.

Tabas, I. Apoptosis and plaque destabilization in atherosclerosis: The role of macrophage apoptosis induced by cholesterol.Cell Death Differ.,2004,11S12-S16.

GHS Gefahren- und Sicherheitshinweise

Sicherheitshinweise: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code


  • H27363

    N-Fmoc-S-trityl-L-cysteine, 95%
  • H32201

    5-Fluoro-2-(trifluoromethoxy)benzyl bromide, 97%
  • A12191

    N-Benzyldimethylamine, 98+%
  • 40120

    Hydrazine sulfate, ACS, 99.0% min
  • B22434

    Acetonyltriphenylphosphonium bromide, 98+%

Kürzlich angesehen


Life science

Metalle und Stoffe


Forschungs- und Laborbedarf