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180002-83-9 - GW-405833 - L-768242 - 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]indole - J67425 - Alfa Aesar

J67425 GW-405833

CAS-Nummer
180002-83-9
Synonyme
L-768242
1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]indole

Größe Preis ($) Menge Verfügbarkeit
10mg 166,00
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GW-405833

MDL
MFCD09832650

Chemische Eigenschaften

Formel
C23H24Cl2N2O3
Molmasse
447.36
Form
Solid
Schmelzpunkt
47-49°
Löslichkeit
Soluble in DMSO at 10-15mg/ml. Also soluble in ethanol at ~5mg/ml.

Anwendungen

It is a potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Bemerkungen

Protect from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in refrigerator at -20°C.

Literaturverweise

LaBuda CJ, et al. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.Eur J Pharmacol.,2005,527(1-3), 172-4.

Valenzano KJ, et al. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.Neuropharmacology.,2005,48(5), 658-72.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H413

Toxic if swallowed. May cause long lasting harmful effects to aquatic life.

Sicherheitshinweise: P273-P264-P270-P301+P310-P321-P330-P405-P501a

Avoid release to the environment. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.99
TSCA
No

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