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It is a potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
LaBuda CJ, et al. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.Eur J Pharmacol.,2005,527(1-3), 172-4.
Valenzano KJ, et al. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.Neuropharmacology.,2005,48(5), 658-72.
Gefahrenhinweise (EU): H301
Toxic if swallowed.
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.