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Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
Walter B. Shelley, MD, PhD.; E. Dorinda Shelley, MD. Intralesional Bleomycin Sulfate Therapy for Warts A Novel Bifurcated Needle Puncture Technique. Arch Dermatol. 1991, 127 (2), 234-236.
R.J. Sollitto, DPM, FACFAS; David M. Pizzano, DPM. Bleomycin sulfate in the treatment of mosaic plantar verrucae: A follow-up study. The Journal of Foot and Ankle Surgery. 2010, 35 (2), 169-172.
Gefahrenhinweise (EU): H340-H351
May cause genetic defects. Suspected of causing cancer.
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