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1-(Heptafluorobutyryl)imidazole is used in gas chromatography for the determination of various pharmaceutical compounds like retronecine in biological matrixes. It acts as a reagent for derivatize amine-groups. It plays an essential role to reduce GC column degradation due to its non-acidic property. It is an acylating agent, which converts thermally unstable compounds to its more volatile derivative and then made suitable for GC analysis.
GC derivatization reagent for amino and hydroxyl groups: Anal. Lett., 1, 311 (1968); 2, 81 (1969); compare Heptafluorobutyric anhydride, A10744.
Zhou, H.; Jin, Q.; Wang, X.; Xu, X. Direct measurement of 3-chloropropane-1,2-diol fatty acid esters in oils and fats by HPLC method. Food Control 2014, 36 (1), 111-118.
Nie, Z.; Zhang, Y.; Chen, J.; Lin, Y.; Wu, B.; Dong, Y.; Feng, J.; Liu, Q.; Xie, J. Monitoring urinary metabolites resulting from sulfur mustard exposure in rabbits, using highly sensitive isotope-dilution gas chromatography-mass spectrometry Anal. Bioanal. Chem. 2014, 406 (21), 5203-5212.
Gefahrenhinweise (EU): H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.