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128-53-0 - N-Ethylmaleimide, 98+% - 1-Ethyl-1H-pyrrole-2,5-dione - NEM - L00355 - Alfa Aesar

L00355 N-Ethylmaleimide, 98+%

CAS-Nummer
128-53-0
Synonyme
1-Ethyl-1H-pyrrole-2,5-dione
NEM

Größe Preis ($) Menge Verfügbarkeit
10g 70,04
50g 232,78
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N-Ethylmaleimide, 98+%

MDL
MFCD00005509
EINECS
204-892-4

Chemische Eigenschaften

Formel
C6H7NO2
Molmasse
125.13
Schmelzpunkt
43-46°
Siedepunkt
209-211°
Flammpunkt
73°(163°F)
Sensitivität
Light Sensitive
Löslichkeit
Soluble in ethanol, water, chloroform, methanol and toluene.

Anwendungen

Cysteine alkylating agent N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg<sup>2+</sup-dependent internucleosomal DNA fragmentation.

Bemerkungen

Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

Literaturverweise

Reactive dienophile and dipolarophile. Reagent for modification of sulfhydryl groups of cysteine residues in proteins: Methods Enzymol., 25, 449 (1972); Eur. J. Biochem., 145, 245 (1984).

Shah, N.; Colbert, K. N.; Enos, M. D.; Herschlag, D.; Weis, W. I. Three alpha-SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF). J. Biol. Chem. 2015, 290 (4), 2175-2188.

Iwasaki, F.; Suga, K.; Umakoshi, H. Pseudo-Interphase of Liposome Promotes 1, 3-Dipolar Cycloaddition Reaction of Benzonitrile Oxide and N-Ethylmaleimide in Aqueous Solution. J. Phys. Chem. B 2015, 119, (30), 9772-9779.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H311-H317-H314-H318

Fatal if swallowed. Toxic in contact with skin. May cause an allergic skin reaction. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P261-P280-P301+P310-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3822
Beilstein
112448
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2925.19
TSCA
Yes
RTECS
UX9625000

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