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55985-85-8 - (2-Carboxyethyl)triphenylphosphonium tribromide, 98+% - L00553 - Alfa Aesar

L00553 (2-Carboxyethyl)triphenylphosphonium tribromide, 98+%

CAS-Nummer
55985-85-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 39,40
25g 126,00
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(2-Carboxyethyl)triphenylphosphonium tribromide, 98+%

MDL
MFCD00051883

Chemische Eigenschaften

Formel
HO2CCH2CH2P(C6H5)3Br3
Molmasse
575.09
Schmelzpunkt
ca 159° dec.
Sensitivität
Moisture Sensitive
Löslichkeit
It reacts with water. Soluble in THF (25 g/100 mL), dichloromethane, insoluble in alcohol.

Anwendungen

(2-Carboxyethyl)triphenylphosphonium tribromide, is a fine chemical and pharmaceutical intermediate. It is a bromine transfer agent for selective α-bromination of ketones and ketone acetals in the presence of double bonds, activated aromatic rings, esters or another free enolic position.

Bemerkungen

Moisture, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents, bases. This reagent should be handled in a fume hood.

Literaturverweise

SP Nikas.; J Grzybowska.; DP Papahatjis. The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model. The AAPS journal. 20046 (4), 23-35.

A Rybár. Annulated Heterocyclo-Purines II: Fused Six-and More-Membered Heterocyclo-Purinediones,-Purinones and-Purineimines. Advances in Heterocyclic Chemistry. 200588 (1), 175-229.

Reagent for ɑ-bromination of ketones. Unsaturated ketones can be selectivelyɑ-brominated in high yield without bromination of the olefinic double bond: Tetrahedron Lett., 373 (1975); Synth. Commun., 19, 1091 (1989). See also 2-Pyrrolidinone hydrotribromide, L00177 for similar reagent.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
6262851
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2931.39
TSCA
No

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