I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
2,2-Difluorosuccinic acid is used in the preparation of fluorofumaric acid. It is also used in enolate alkylation.
Risley, J. M.; Kastanis, J. P.; Young, A. M. Determination of the second-order 1H NMR parameters for the aromatic protons in 4-fluoroaniline and application to the analysis of the 1H NMR spectra for the aromatic protons in N4-(4'-fluorophenyl)succinamic acid and in N4-(4'-fluorophenyl)-3,3-difluorosuccinamic acid. J. Fluorine Chem. 2011, 132 (4), 269-275.
Hagan, D. O. Organofluorine Chemistry: Synthesis and Conformation of Vicinal Fluoromethylene Motifs. J. Org. Chem. 2012, 77 (8), 3689-3699.
Perrin, C. L.; Karri, P.; Moore, C.; Rheingold, A. L. Hydrogen-Bond Symmetry in Difluoromaleate Monoanion. J. Am. Chem. Soc. 2012, 134 (18), 7766-7772.
McAlpine, I.; Tran-Dubé, M.; Wang, F.: Scales, S.; Matthews, J.; Collins, M. R.; Nair, S. K.; Nguyen, M.; Bian, J.; Alsina, L.M.; Sun, J.; Zhong, J.; Warmus, J. S.; ONeill, B. T. Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry. J. Org. Chem. 2015, 80 (14), 7266-7274.
Gefahrenhinweise (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.