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33884-43-4 - 2-(2-Bromoethyl)-1,3-dioxane, 98% - 2-Bromopropanal 1,3-propanediol acetal - 2-Bromopropionaldehyde trimethylene acetal - L00958 - Alfa Aesar

L00958 2-(2-Bromoethyl)-1,3-dioxane, 98%

CAS-Nummer
33884-43-4
Synonyme
2-Bromopropanal 1,3-propanediol acetal
2-Bromopropionaldehyde trimethylene acetal

Größe Preis ($) Menge Verfügbarkeit
10g 26,06
50g 89,82
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2-(2-Bromoethyl)-1,3-dioxane, 98%

MDL
MFCD00006567
EINECS
251-716-7

Chemische Eigenschaften

Formel
C6H11BrO2
Molmasse
195.06
Siedepunkt
67-70°/3mm
Flammpunkt
96°(204°F)
Dichte
1.434
Brechungsindex
1.4820
Löslichkeit
It is not soluble in water but soluble in organic solvent such as ethanol.

Anwendungen

2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.

Bemerkungen

Air, Heat sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Literaturverweise

JC Stowell. New. gamma.-keto Aldehyde synthesis. The Journal of Organic Chemistry. 197641(3) , 560-561.

A Fadel.; P Arzel. Asymmetric construction of benzylic quaternary carbons by lipase-mediated enantioselective transesterification of prochiral α, α-disubstituted 1, 3-propanediols. Tetrahedron: Asymmetry. 19978(2) , 283-291.

Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde: J. Org. Chem., 41, 560 (1976).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1421628
Harmonized Tariff Code
2932.99
TSCA
Yes

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