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776-74-9 - Benzhydryl bromide, 90+% - Bromodiphenylmethane - Diphenylmethyl bromide - L02211 - Alfa Aesar

L02211 Benzhydryl bromide, 90+%

CAS-Nummer
776-74-9
Synonyme
Bromodiphenylmethane
Diphenylmethyl bromide

Größe Preis ($) Menge Verfügbarkeit
25g 21,00
100g 43,20
500g 159,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Benzhydryl bromide, 90+%

MDL
MFCD00000134
EINECS
212-279-8

Chemische Eigenschaften

Formel
C13H11Br
Molmasse
247.14
Schmelzpunkt
36-41°
Siedepunkt
183-185°/20mm
Flammpunkt
>110°(230°F)
Sensitivität
Moisture Sensitive
Löslichkeit
Insoluble in water.

Anwendungen

Benzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.

Bemerkungen

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents and bases. It is sensitive to moisture. Protect from humidity and water. Store under dry inert gas.

Literaturverweise

S. Winstein.; Arnold H. Fainberg.; E. Grunwald. Correlation of Solvolysis Rates. VIII. Benzhydryl Chloride and Bromide. Comparison of mY and Swain's Correlations. J. Am. Chem. Soc. 1957, 79 (15), 4146-4155.

Anu Mahadevan.; Howard Sard.; Mario Gonzalez.; John C. McKew. A general method for C3 reductive alkylation of indoles. Tetrahedron Letters. 2003, 44(24), 4589-4591.

The benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis: Synth. Commun., 21, 611 (1991).

Compare also Benzhydrol, A12884.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell:

Weitere Referenzen

Beilstein
638544
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
PA5350000

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