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10147-37-2 - 2-Propanesulfonyl chloride, 97% - Isopropylsulfonyl chloride - L02431 - Alfa Aesar

L02431 2-Propanesulfonyl chloride, 97%

CAS-Nummer
10147-37-2
Synonyme
Isopropylsulfonyl chloride

Größe Preis ($) Menge Verfügbarkeit
5g 37,90
25g 102,60
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2-Propanesulfonyl chloride, 97%

MDL
MFCD00007453
EINECS
233-415-2

Chemische Eigenschaften

Formel
(CH3)2CHSO2Cl
Molmasse
142.60
Schmelzpunkt
-47°
Siedepunkt
95°/45mm
Flammpunkt
86°(186°F)
Dichte
1.273
Brechungsindex
1.4560
Sensitivität
Moisture Sensitive
Löslichkeit
Reacts with water.

Anwendungen

2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.

Bemerkungen

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents and bases. Store under dry inert gas. It is sensitive to moisture.

Literaturverweise

James F. King.; Joe Y. L. Lam.; Vinod Dave. tert-Butyl Cation Formation in the Hydrolysis of 2-Methyl-2-propanesulfonyl Chloride, the Simplest Tertiary Alkanesulfonyl Chloride. J. Org. Chem. 1995, 60 (9), 2831-2834.

Dennis N. Kevill.; Byoung-Chun Park.; Kyoung-Ho Park.; Malcolm J. D'Souza.; Lamia Yaakoubd.; Stacey L. Mlynarski.; Jin Burm Kyong. Rate and product studies in the solvolyses of N,N-dimethylsulfamoyl and 2-propanesulfonyl chlorides. Org. Biomol. Chem. 2006, 4(8), 1580-1586.

Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride. Reduction of the mesylate and tosylate yielded only the starting alcohol: J. Am. Chem. Soc., 107, 4088 (1985).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Sicherheitshinweise: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1747497
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2904.10
TSCA
No

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