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3173-56-6 - Benzyl isocyanate, 98% - L02633 - Alfa Aesar

L02633 Benzyl isocyanate, 98%

CAS-Nummer
3173-56-6
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 23,40
5g 59,60
25g 201,00
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Benzyl isocyanate, 98%

MDL
MFCD00009701
EINECS
221-640-9

Chemische Eigenschaften

Formel
C8H7NO
Molmasse
133.15
Siedepunkt
53-54°/0.8mm
Flammpunkt
43°(109°F)
Dichte
1.078
Brechungsindex
1.5250
Sensitivität
Moisture Sensitive
Löslichkeit
It hydrolyzes with water.

Anwendungen

Benzyl isocyanate, is used as a protected ammonia equivalent in the stereo selective ring-opening of chiral 2,3-epoxy alcohols (from Sharpless asymmetric epoxidation). The key step in the sequence involves intramolecular cyclization of the carbamate intermediate. It is also used in a multicomponent, stereospecific synthesis of 1,3-oxazinane-2,4-diones employing an Al-salph complex.

Bemerkungen

Moisture& heat Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from alcohols, amines.

Literaturverweise

LL Ferstandig.; RA Scherrer. Mechanism of Isocyanate Reactions with Ethanol1. J. Am. Chem. Soc. 195981(18) , 4838-4842.

DG Hoare.; DE Koshland Jr. A procedure for the selective modification of carboxyl groups in proteins. J. Am. Chem. Soc. 196688(9) , 2057-2058.

Protected ammonia equivalent in the stereoselective ring-opening of chiral 2,3-epoxy alcohols (from Sharpless asymmetric epoxidation). The key step in the sequence involves intramolecular cyclization of the carbamate intermediate: J. Org. Chem., 50, 3752 (1985):

For general reactions of isocyanates, see Appendix 3.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H301-H330-H315-H319-H334-H335

Flammable liquid and vapour. Toxic if swallowed. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

Sicherheitshinweise: P301+P310a-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501a

IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
636508
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2929.10
TSCA
No

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