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38870-89-2 - Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide - L03210 - Alfa Aesar

L03210 Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

CAS-Nummer
38870-89-2
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 38,40
25g 116,00
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Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

MDL
MFCD00000728
EINECS
254-169-2

Chemische Eigenschaften

Formel
CH3OCH2COCl
Molmasse
108.52
Schmelzpunkt
<-40°
Siedepunkt
112-113°
Flammpunkt
28°(82°F)
Dichte
1.185
Brechungsindex
1.4240
Sensitivität
Moisture Sensitive
Löslichkeit
Miscible with acetone, ether, carbon tetrachloride and chloroform.

Anwendungen

Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.

Bemerkungen

Moisture sensitive. Store in a cool place. Incompatible with water, alcohols, oxidizing agents and strong bases.

Literaturverweise

Reagent for the chloromethylation of aromatics under Friedel-Crafts conditions, avoiding the use of chloromethyl methyl ether: Tetrahedron Lett., 24, 1933 (1983). For a study of the kinetics of chloromethylation of benzene and toluene in the presence of SnCl4, see: J. Org. Chem., 62, 2694 (1997). Compare Methoxyacetic acid, B22917.

Has also been used for the protection of alcohols as methoxyacetate esters, formed in the presence of pyridine, and cleaved using methanolic or aqueous ammonia ca. 20x faster than acetate: Tetrahedron Lett., 4273 (1968). Selective cleavage with Yb(OTf)3: J. Org. Chem., 61, 4491 (1996), or ethanolamine in IPA: J. Org. Chem., 60, 331 (1995), have also been reported.

Tiwari, D. K.; Pogula, J.; Tiwari, D. K. A general and practical route to 4,5-disubstituted oxazoles using acid chlorides and isocyanides. RSC Adv. 2015, 5 (65), 53111-53116.

Zadehahmadi, F.; Ahmadi, F.; Tangestaninejad, S.; Moghadam, M.; Mirkhani, V.; Mohammadpoor-Baltork, I.; Kardanpour, R. Catalytic CO2 fixation using tin porphyrin supported on organic and inorganic materials under mild conditions. J. Mol. Catal. A: Chem. 2015, 398, 1-10.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H331-H314-H318

Flammable liquid and vapour. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor

Weitere Referenzen

Beilstein
1740244
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2918.99
TSCA
No

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