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507-09-5 - Thioacetic acid, 97% - Thiolacetic acid - L03305 - Alfa Aesar

L03305 Thioacetic acid, 97%

CAS-Nummer
507-09-5
Synonyme
Thiolacetic acid

Größe Preis ($) Menge Verfügbarkeit
25g 20,61
100g 37,90
500g 98,10
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Thioacetic acid, 97%

MDL
MFCD00004853
EINECS
208-063-8

Chemische Eigenschaften

Formel
C2H4OS
Molmasse
76.12
Schmelzpunkt
-17°
Siedepunkt
97°
Flammpunkt
18°(64°F)
Dichte
1.068
Brechungsindex
1.4640
Löslichkeit
Soluble in water. (27g/L) at 16°C.

Anwendungen

Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).

Bemerkungen

Protect from heat. Store away from oxidizing agents. Incompatible with strong bases, strong oxidizing agents, metals.

Literaturverweise

Wen Yang; Da-Ming Du. Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes.Organic & Biomolecular Chemistry.2012, 10 (34), 6876-6884.

Libo Hu; Hui Zhu; Da-Ming Du; Jiaxi Xu. Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines.Journal of Organic Chemistry.2007, 72 (12), 4543-4546.

Used in several different ways for the introduction of the thiol group: Radical addition to unactivated alkenes: J. Chem. Soc., 2123 (1951). Conjugate (Michael) addition to activated double bonds: J. Am. Chem. Soc., 77, 5144 (1955); 81, 1224 (1959). Nucleophilic displacement of halide, tosylate or acetate: J. Am. Chem. Soc., 73, 2659 (1951); Carbohydr. Res., 17, 457 (1971). Alcohols can be converted to thiol esters under Mitsunobu conditions, followed by LAH reduction to the thiol: Tetrahedron Lett., 3119 (1981).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H314-H318-H302-H332-H317

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Harmful if inhaled. May cause an allergic skin reaction.

Sicherheitshinweise: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9320
Beilstein
773684
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
AJ5600000

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