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β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
Liu, X.; Liu, Y.; Cheng, M.; Zhang, X.; Xiao, H. A metabolomics study of the inhibitory effect of 17-beta-estradiol on osteoclast proliferation and differentiation. Mol. Biosyst. 2015, 11 (2), 635-646.
Pooley, A. E.; Luong, M.; Hussain, A.; Nathan, B. P. Neurite outgrowth promoting effect of 17-beta estradiol is mediated through estrogen receptor alpha in an olfactory epithelium culture. Brain Res. 2015, 1624, 19-27.
Gefahrenhinweise (EU): H350-H360
May cause cancer. May damage fertility or the unborn child.
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