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3128-06-1 - 4-Acetylbutyric acid, 97% - 5-Ketohexanoic acid - 5-Oxohexanoic acid - L03978 - Alfa Aesar

L03978 4-Acetylbutyric acid, 97%

CAS-Nummer
3128-06-1
Synonyme
5-Ketohexanoic acid
5-Oxohexanoic acid

Größe Preis ($) Menge Verfügbarkeit
5g 38,70
25g 128,00
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4-Acetylbutyric acid, 97%

MDL
MFCD00004412
EINECS
221-511-7

Chemische Eigenschaften

Formel
CH3CO(CH2)3CO2H
Molmasse
130.14
Schmelzpunkt
12-14°
Siedepunkt
274-275°
Flammpunkt
>110°(230°F)
Dichte
1.100
Brechungsindex
1.4451
Löslichkeit
Slightly soluble in water, chloroform and methanol.

Anwendungen

4-Acetylbutyric acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. It is also used to prepare PARP inhibitors for the treatment of cancer.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.

Literaturverweise

Andy J. Liedtke; Adegoke O. Adenij; Mo Chen; Michael C. Byrns; Yi Jin; David W. Christianson; Lawrence J. Marnett and Trevor M. Penning. Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer.J. Med. Chem.2013, 56 (6), 2429-2446.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
385840
Harmonized Tariff Code
2918.30
TSCA
Yes

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