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3279-26-3 - Methyl phosphorodichloridite, 98% - Methyl dichlorophosphite - L04588 - Alfa Aesar

L04588 Methyl phosphorodichloridite, 98%

CAS-Nummer
3279-26-3
Synonyme
Methyl dichlorophosphite

Größe Preis ($) Menge Verfügbarkeit
5g 63,96
25g 201,60
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Methyl phosphorodichloridite, 98%

MDL
MFCD00000524
EINECS
221-915-3

Chemische Eigenschaften

Formel
CH3Cl2OP
Molmasse
132.91
Siedepunkt
92-93°
Flammpunkt
40°(104°F)
Dichte
1.375
Brechungsindex
1.4850
Sensitivität
Moisture Sensitive
Löslichkeit
Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.

Anwendungen

Methyl phosphorodichloridite is a reagent for the phosphite coupling method of oligonucleotide synthesis. It is employed in the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides, 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol, deoxyoligonucleotides on a polymer support, cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane, phosphorodichloridothioates and oxazaphosphorinanes.

Bemerkungen

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to moisture. Store under dry inert gas.

Literaturverweise

Hiroshi Sugiyama.; Cheng Xu.; Natesan Murugesan.; Sidney M. Hecht.; Gijs A. Van der Marel.; Jacques H. Van Boom. Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG). Biochemistry. 1988, 27 (1), 58-673.

Louis d. quin.; Charles h. rolston. Preparation of Trichloromethylphosphonous Dichloride. Reduction of Tetrachlorophosphoranes with Methyl Phosphorodichloridite. J. Org. Chem. 1958, 23 (11), 1693-1694.

Key reagent for the phosphite coupling method of oligonucleotide synthesis: Tetrahedron Lett., 1859 (1981).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Sicherheitshinweise: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1697452
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2920.90
TSCA
No

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