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Methyl phosphorodichloridite is a reagent for the phosphite coupling method of oligonucleotide synthesis. It is employed in the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides, 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol, deoxyoligonucleotides on a polymer support, cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane, phosphorodichloridothioates and oxazaphosphorinanes.
Hiroshi Sugiyama.; Cheng Xu.; Natesan Murugesan.; Sidney M. Hecht.; Gijs A. Van der Marel.; Jacques H. Van Boom. Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG). Biochemistry. 1988, 27 (1), 58-673.
Louis d. quin.; Charles h. rolston. Preparation of Trichloromethylphosphonous Dichloride. Reduction of Tetrachlorophosphoranes with Methyl Phosphorodichloridite. J. Org. Chem. 1958, 23 (11), 1693-1694.
Key reagent for the phosphite coupling method of oligonucleotide synthesis: Tetrahedron Lett., 1859 (1981).
Gefahrenhinweise (EU): H226-H314-H318
Flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.