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2-Methyl-3-butyn-2-ol is used as an intermediate in the manufacture of products for the agrochemical and specialty chemical industry.
Edward T. Sabourin.; Anatoli Onopchenko. A convenient synthesis of 4-ethynylphthalic anhydride via 2-methyl-3-butyn-2-ol. J. Org. Chem. 1983, 48, (25), 5135-5137.
D. Boyall.; F. López.; H. Sasaki.; D. Frantz.; E. M. Carreira. Enantioselective Addition of 2-Methyl-3-butyn-2-ol to Aldehydes:? Preparation of 3-Hydroxy-1-butynes. Org. Lett. 2000, 2, (26), 4233-4236.
Adduct of acetylene and acetone which acts as an acetylene equivalent in the Pd-catalyzed (Sonogashira) coupling reaction with aryl or heteroaryl halides, permitting a one-pot diarylation by different halides: Synthesis, 571 (1984):
Alternatively, the protecting group can be removed from the intermediate by base to give monoarylacetylenes: J. Org. Chem., 48, 5135 (1983); 57, 6998 (1992). For an improved procedure, see: Synthesis, 589 (1996).
Gefahrenhinweise (EU): H225-H302-H318
Highly flammable liquid and vapour. Harmful if swallowed. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Dispose of contents/container in accordance with local/regional/national/international regulations.