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115-20-8 - 2,2,2-Trichloroethanol, 99% - L08163 - Alfa Aesar

L08163 2,2,2-Trichloroethanol, 99%

CAS-Nummer
115-20-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 18,75
25g 22,68
100g 33,48
500g 133,20
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2,2,2-Trichloroethanol, 99%

MDL
MFCD00004677
EINECS
204-071-0

Chemische Eigenschaften

Formel
Cl3CCH2OH
Molmasse
149.40
Schmelzpunkt
17-18°
Siedepunkt
151-153°
Flammpunkt
>110°(230°F)
Dichte
1.560
Brechungsindex
1.4895
Sensitivität
Hygroscopic
Löslichkeit
Slightly soluble in water.

Anwendungen

2,2,2-Trichloroethanol is used as a sedative or a hypnotic. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Bemerkungen

Hygroscopic. Store away from water and oxidizing agents. Protect from humidity and water. Incompatible with oxidizing agents, Strong acids, Strong bases, Strong reducing agents, Acid chlorides, Acid anhydrides.

Literaturverweise

Maurice R. Eftink; James L. Zajicek; Camillo A. Ghiron. A Hydrophobic Quencher of Protein Fluorescence: 2,2,2-Trichloroethanol. Biochimica et Biophysica Acta (BBA) - Protein Structure. 1977, 491 473-481.

M. Perttilä. Vibrational spectra and normal coordinate analysis of 2,2,2-trichloroethanol and 2,2,2-trifluoroethanol. Spectrochimica Acta Part A: Molecular Spectroscopy. 1979, 35 585-592.

Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH4 in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.

Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).

Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H318-H315-H302-H336

Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause drowsiness or dizziness.

Sicherheitshinweise: P280-P305+P351+P338-P308+P313-P330-P501a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9638
Beilstein
1697495
Harmonized Tariff Code
2905.59
TSCA
Yes
RTECS
KM3850000

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