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17145-91-4 - Triethyl 2-phosphonobutyrate, 97% - Diethyl 1-(ethoxycarbonyl)propanephosphonate - 2-Phosphonobutyric acid triethyl ester - L09329 - Alfa Aesar

L09329 Triethyl 2-phosphonobutyrate, 97%

CAS-Nummer
17145-91-4
Synonyme
Diethyl 1-(ethoxycarbonyl)propanephosphonate
2-Phosphonobutyric acid triethyl ester

Größe Preis ($) Menge Verfügbarkeit
5g 35,74
25g 109,14
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Triethyl 2-phosphonobutyrate, 97%

MDL
MFCD00041347

Chemische Eigenschaften

Formel
C10H21O5P
Molmasse
252.25
Siedepunkt
105-106°/2mm
Flammpunkt
>110°(230°F)
Dichte
1.064
Brechungsindex
1.4330
Löslichkeit
Not miscible or difficult to mix with water.

Anwendungen

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Bemerkungen

Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Yuan Cheng et. al. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).. Journal of medicinal and pharmaceutical chemistry,2011, 54 (16), 5836-5857.

Shintaro Ban et. al. Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. Bioorganic & Medicinal Chemistry,2011, 19(10), 3183-3191.

Intermediate for Wadsworth-Emmons formation of ɑ-ethylacrylic esters. See Appendix 1.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Weitere Referenzen

Beilstein
1789280
Harmonized Tariff Code
2931.90
TSCA
No

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