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Through the stereo displacement of (S)-(-)-2-Chloropropionic acid PPAR Agonist can be synthesized via asymmetric hydrogenation of a cinnamic acid derivative.
Ioannis N. Houpis.; Lawrence E. Patterson.; Charles A. Alt.; John R. Rizzo.; Tony Y. Zhang.; Michael Haurez. Synthesis of PPAR Agonist via Asymmetric Hydrogenation of a Cinnamic Acid Derivative and Stereospecific Displacement of (S)-2-Chloropropionic Acid.Org. Lett. 2005, 7 (10),1947-1950 .
Atsushi Kurata.; Tatsuo Kurihara.; Harumi Kamachi.; Nobuyoshi Esaki. Asymmetric reduction of 2-chloroacrylic acid to (S)-2-chloropropionic acid by a novel reductase from Burkholderia sp. WSTetrahedron: Asymmetry. 2004, 15 (18),2837-2839 .
Gefahrenhinweise (EU): H302-H312-H314-H318
Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.
Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.