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22128-62-7 - Chloromethyl chloroformate, 97% - Chloroformic acid chloromethyl ester - L09527 - Alfa Aesar

L09527 Chloromethyl chloroformate, 97%

CAS-Nummer
22128-62-7
Synonyme
Chloroformic acid chloromethyl ester

Größe Preis ($) Menge Verfügbarkeit
10g 64,40
50g 237,00
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Chloromethyl chloroformate, 97%

MDL
MFCD00077688
EINECS
244-793-3

Chemische Eigenschaften

Formel
C2H2Cl2O2
Molmasse
128.94
Schmelzpunkt
<-20°
Siedepunkt
107-108°
Flammpunkt
95°(203°F)
Dichte
1.465
Brechungsindex
1.4295
Sensitivität
Moisture Sensitive
Löslichkeit
Slightly miscible with water.

Anwendungen

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Bemerkungen

Incompatible with oxidizing agents and water.

Literaturverweise

Naganathan, S.; Andersen, D. L.; Andersen, N. G.; Lau, S.; Lohse, A.; Sorensen, M. D. Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor. Org. Process Res. Dev. 2015, 19 (7), 721-734.

Wu, P.; Petersen, M. A.; Cohrt, A. E.; Petersen, R.; Clausen, M. H.; Nielsen, T. E. Reductive Cyclization and Petasis-Like Reaction for the Synthesis of Functionalized γ-Lactams. Eur. J. Org. Chem. 2015, 2015 (11), 2346-2350.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H331-H302-H314-H318

Toxic if inhaled. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P280-P232-P305+P351+P338-P309-P310-P402

Wear protective gloves/protective clothing/eye protection/face protection. Protect from moisture. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician. Store in a dry place.

Weitere Referenzen

Beilstein
506426
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
No

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