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288-47-1 - Thiazole, 99% - L09970 - Alfa Aesar

L09970 Thiazole, 99%

CAS-Nummer
288-47-1
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 36,67
5g 113,30
25g 332,10
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Thiazole, 99%

MDL
MFCD00005315
EINECS
206-021-3

Chemische Eigenschaften

Formel
C3H3NS
Molmasse
85.13
Schmelzpunkt
-33°
Siedepunkt
117-118°
Flammpunkt
22°(71°F)
Dichte
1.200
Brechungsindex
1.5390
Sensitivität
Air & Light Sensitive
Löslichkeit
Soluble in ethanol and ether. Slightly soluble in water.

Anwendungen

Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignard’s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.

Bemerkungen

Air and light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

Literaturverweise

For an example of 2-lithiation, see: J. Med. Chem., 37, 3492 (1994). For other uses of 2-lithiothiazole, see 2-Bromothiazole, A14838.

Li, F.; Meng, F.; Wang, Y.; Zhu, C.; Cheng, Y. Polymer-based fluorescence sensor incorporating thiazole moiety for direct and visual detection of Hg2+ and Ag+. Tetrahedron 2015, 71 (11), 1700-1704.

Mallia, C. J.; Englert, L.; Walter, G. C.; Baxendale, I. R. Thiazole formation through a modified Gewald reaction. Beilstein J. Org. Chem. 2015, 11, 875-883.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H302-H319

Highly flammable liquid and vapour. Harmful if swallowed. Causes serious eye irritation.

Sicherheitshinweise: P210-P261-P280f-P305+P351+P338

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Merck
14,9307
Beilstein
103852
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2934.10
TSCA
Yes
RTECS
XJ1290000

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