6-(carboxymethylureido)-(±)-nicotine (CMUNic)was prepared by using ethyl isocyanatoacetate. Ethyl isocyanatoacetate has been used in the preparation of nicotine immunogen, ethyl 8-carbamoyl-4-oxo-3,4-dihydroimidazo[5,1-d]-1,2,3,5-tetrazin-3-ylacetate, imidazo[1,2-c]-quinazoline-2,5-(3H,6H)dione.
Y Hieda et. al. Active immunization alters the plasma nicotine concentration in rats. Journal of Pharmacology and Experimental Therapeutics. 1997, 283, (3), 1076-1081.
Malcolm FG. Antitumour imidazotetrazines. Part 33. New syntheses of the antitumour drug temozolomide using 'masked'methyl isocyanates. . J. Chem. Soc. Perkin Trans. 1995, 121 2783-87.
Gefahrenhinweise (EU): H227-H302-H315-H319-H334-H335
Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.