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69304-37-6 - 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97% - L11171 - Alfa Aesar

L11171 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

CAS-Nummer
69304-37-6
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 51,40
5g 171,00
25g 547,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

MDL
MFCD00009655
EINECS
000-000-0

Chemische Eigenschaften

Formel
C12H28Cl2OSi2
Molmasse
315.43
Siedepunkt
69-70°/0.5mm
Flammpunkt
>110°(230°F)
Dichte
0.986
Brechungsindex
1.4540
Sensitivität
Moisture Sensitive
Löslichkeit
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.

Anwendungen

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Bemerkungen

Incompatible with strong oxidizing agents and water.

Literaturverweise

Reagent for the protection of diols, including carbohydrate-type molecules, as their 1,3-(1,1,3,3-tetraisopropyldisiloxanylidene) (TIPDS) derivatives, formed in the presence of imidazole: J. Chem. Res. Synop., 24 (1979); J. Org. Chem., 50, 1651 (1985), or pyridine-DMF: Tetrahedron, 41, 4545, 4557 (1985). The high steric demand of the TIPDS group enables discrimination between primary and secondary OH. It is readily cleaved by F- (e.g. TBAF in THF) or by aqueous acid or base. See Appendix 4.

Osawa, T.; Hari, Y.; Dohi, M.; Matsuda, Y.; Obika, S. Synthesis and Properties of the 5-Methyluridine Derivative of 3,4-Dihydro-2H-pyran-Bridged Nucleic Acid (DpNA). J. Org. Chem. 2015, 80 (21), 10474-10481.

Clobes, C.; Jerabek, P.; Nußbruch, I.; Frenking, G.; von Hänisch, C. Stepwise Synthesis of Siloxane-Substituted Oligoarsanes and Structural Investigation of Alkaline Earth Metal Derivatives. Eur. J. Inorg. Chem. 2015, 2015 (20), 3264-3273.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1934216
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2931.90
TSCA
No

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